15-epi-Lipoxin A4 is an aspirin-triggered eicosanoid believed to be involved in the positive attributes of aspirin therapy for heart, cancer and human immunodeficiency virus patients. During inflammation, neutrophils are activated. 15-epi-LXA4, when administered in vivo, inhibits neutrophil activation and dampens inflammation (Takano, 1997). 15-epi-LXA4 is naturally formed in the body via this pathway:
Arachidonic Acid (AA)→15(R) -HETE→15-epi-LXA4
Aspirin is thought to be involved in the acetylation of prostaglandin G/H synthase, which triggers the conversion of AA to 15(R)-HETE. The development of this assay, which is both sensitive and selective for 15-epi-LXA4, will be essential to researchers studying anti-inflammatory medications.
Standard Curve in EIA Buffer
|Product #||Product Description|
|407110||15-epi-Lipoxin A4, 96 well kit|
Kit inserts available on our website are for reference use only and are subject to change. It is always recommended to use the protocol included with the kit.
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